The Comparison of intravesical hyaluronic acid and other modalities for the improvement of interstitial cystitis symptoms: a systematic reviews and meta-analysis

Background: Interstitial cystitis (IC) is a chronic inflammation of the bladder which causes unpleasant sensations. This condition considerably reduces patients' quality life. Intravesical hyaluronic acid one new interventions for interstitial management, in thorough review and meta-analysis regarding this topic are still limited. study aimed to compare efficacy intravesical with other treatment modalities available treat cystitis.Method: Systematic literature searching main keywords "interstitial cystitis" or "bladder pain syndrome" "intravesical acid" was conducted. The outcome assessment using visual analogue scale (VAS) Cystitis Symptoms Index (ICSI), problem index (ICPI). Meta-analysis carried out when comparative studies were available. Eleven obtained assess acid's effects, including three meta-analysis. treatments found as comparison heparin chondroitin sulphate.Result: There significant heterogeneity among included all parameters. pooled analysis showed no difference VAS reduction, improvement ICSI ICPI score (p = 0.11, p 0.35, 0.28, respectively) between treatments.Conclusion: treatments. However, further research larger sample needed confirm best cystitis.